2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species
  4. Antiproliferative agent-7

Antiproliferative agent-7 (compound 8f) 是一种有效的抗增殖剂。Antiproliferative agent-7 对癌细胞 MCF-7、MDA-MB-231、HCT-116 和 FR-2 具有抗增殖活性，IC50 分别为 3.5 μM、15.54 μM、30.43 μM 和 34.8 μM。Antiproliferative agent-7 可促进 ROS 产生，诱导细胞凋亡 (apoptosis)。

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Antiproliferative agent-7 Chemical Structure

Antiproliferative agent-7 Chemical Structure

CAS No. : 2497687-47-3

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Antiproliferative agent-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis[1].

IC50 & Target

IC50: 3.5 μM (MCF-7), 15.54 μM (MDA-MB-231), 30.43 μM (HCT-116), 34.8 μM (FR-2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
30.43 μM
Compound: 8f
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
MCF7 IC50
3.5 μM
Compound: 8f
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
MDA-MB-231 IC50
15.54 μM
Compound: 8f
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
分子量

440.58

Formula

C28H32N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-7 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-72497687-47-3Antiproliferative agent7Antiproliferative agent 7ApoptosisReactive Oxygen SpeciesAntiproliferativeMCF-7MDA-MB-231HCT-116FR-2Inhibitorinhibitorinhibit

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