Antitubercular agent-28 

Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC₅₀ value of 1.5 µM, an MIC value of 4.5 µM, an IC₉₀ value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity^[1].

Antitubercular agent-28 (compound 2) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC₅₀s of 2.9, 125, 130, 1.3, 3.8 µM, MICs of 3.3, 170, 190, 1.8, 8.4 µM, IC₉₀s of 3.1, 140, 180, 1.5, 4.8 µM for FQ-R1, INH-R1, INH-R2, RIF-R1,RIF-R2 respectively^[1].
Antitubercular agent-28 (0-200 µM) shows antibacterial activity with an MIC value of 170 µM, IC₅₀ value of 2.96 µM, and IC₉₀ value of 19 µM in low oxygen condition, and an MIC value of 1.77 µM, IC₅₀ value of 1.02 µM, and IC₉₀ value of 1.34 µM in normal oxygen condition^[1].
Antitubercular agent-28 (0-200 µM) shows intracellular activity with an IC₅₀ value of 2.15 µM, and IC₉₀ value of 2.85 µM, and low cytotoxicity with an IC₅₀ value of >100 µM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

306.32

C₁₇H₁₄N₄O₂

2460651-10-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Patel H, et al. Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis. Bioorg Chem. 2020 Sep;102:104099.  [Content Brief]