2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-115

Antitumor agent-115 (SS-12) 是一种有效的体外抗肿瘤化合物，其对小鼠乳腺癌细胞系 4T1 细胞的 IC50 值为 0.34 μM-24.14 μM。Antitumor agent-115 具有阻滞小鼠乳腺癌细胞系 4T1 细胞周期，降低线粒体膜电位，诱导细胞凋亡的作用，针对 4T1 细胞活力的 IC50 值为8-25 μmol/L，可用于乳腺癌疾病的研究。

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Antitumor agent-115 Chemical Structure

Antitumor agent-115 Chemical Structure

CAS No. : 2759277-20-6

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Antitumor agent-115 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-115 (SS-12) is an effective anti-tumor compound with an IC50 value of 0.34 μM-24.14 μM for cell line 4T1. Antitumor agent-115 can block the cell cycle of mouse breast cancer cell line 4T1, reduce the mitochondrial membrane potential, and induce apoptosis, and the IC50 value is 8-25 μmol/L for cell viability. Antitumor agent-115 can be used for breast cancer research[1].

体外研究
(In Vitro)

Antitumor agent-115 (SS-12) (1.25 μM, 10 μm, 40 μM, 24 小时) 主要通过使细胞周期停滞在 G0/G1 阶段来诱导 4T1 细胞凋亡[1]。
Antitumor agent-115 (15 μM, 30 μM, 60 μM, 24小时) 抑制 4T1 细胞的迁移和侵袭[1]。
Antitumor agent-115 (10 μM, 24小时) 通过线粒体途径诱导 4T1 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-115 相关抗体:

Cell Viability Assay[1]

Cell Line: 4T1 cell
Concentration: 1-128 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited 4T1 cells proliferation with IC50 value of 8-25 μM.

Apoptosis Analysis[1]

Cell Line: 4T1 cell
Concentration: 1.25 μM, 10 μM, 40 μM
Incubation Time: 24 h
Result: Increased apoptosis rates of 4T1 cell at concentration of 1.25 μM.

Cell Cycle Analysis[1]

Cell Line: 4T1 cell
Concentration: 1.25 μM, 10 μM, 40 μM
Incubation Time: 24 h
Result: Increased the proportion in the G0/G1 phase and decreased in the S and G2/M phases of 4T1 cells.

Cell Migration Assay [1]

Cell Line: 4T1 cell
Concentration: 15 μM, 30 μM, 60 μM
Incubation Time: 24 h
Result: Expanded the wound area and inhibited cell migration and invasion at concentration of 0.03 μM.

Western Blot Analysis[1]

Cell Line: 4T1 cell
Concentration: 10 μM
Incubation Time: 24 h
Result: Improved the cleaved caspase-3 expression and and Bax expression, but inhibited the anti-apoptosis protein Bcl2 expression in 4T1 cells.
体内研究
(In Vivo)

Antitumor agent-115 (SS-12) (10 mg stachydrine/kg equivale, 200 μL, 口服给药) 在大鼠体内具有较高的生物利用度[1]。
Antitumor agent-115 (0.1 mL/10 g, 口服给药) 在乳腺癌模型小鼠中具有抗肿瘤作用，并改善模型小鼠脾脏的形态结构[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 10 mg stachydrine/kg equivale, 200 μL
Administration: Oral administration (p. o.)
Result: Exhibited high systemic exposure with 6.10 μg/mL of Cmax value and 14.75 h μg/mL of AUC0-t value.
Animal Model: Tumor-bearing mice[1]
Dosage: 0.2 mmol/kg
Administration: Oral administration (p. o.)
Result: Inhibitory rate was 51.47% ( P < 0.01)
Displayed significant tumor cell shrinkage and larger void areas in tumor tissues
Exhibited more weight loss than the model group and other treatment groups, increased of both AST and ALT levels and reduced spleen index of the tumor-bearing mice
分子量

347.96

Formula

C19H38ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-115 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-1152759277-20-6Antitumor agent115Antitumor agent 115Apoptosisstachydrinebreast cancerbioavailability4T1Inhibitorinhibitorinhibit

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