2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Antitumor agent-136

Antitumor agent-136 (Compound 17) 是一种有效的广谱抗肿瘤剂，也是 NAMPT 抑制剂 IC50 为 9.5 nM。Antitumor agent-136 可通过泛素蛋白酶体途径降低细胞内和细胞外NAMPT 蛋白的水平，实现了对肿瘤的抑制。

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Antitumor agent-136 Chemical Structure

Antitumor agent-136 Chemical Structure

CAS No. : 2484876-94-8

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Antitumor agent-136 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a NAMPT inhibitor with an IC50 of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular NAMPT protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition[1].

IC50 & Target

IC50: 9. 5 nM (NAMPT)[1].
分子量

1185.48

Formula

C58H76N10O11S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-136 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-1362484876-94-8Antitumor agent136Antitumor agent 136NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorInhibitorinhibitorinhibit

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