2. Apoptosis
  3. Necroptosis
  4. Antitumor agent-145

Antitumor agent-145 (Compound Ir5) 是一种肿瘤抑制剂，具有显著荧光和线粒体靶向性，其激发波长是 405 nm，通过诱导 necroptosis 以及激活程序性坏死相关的免疫反应发挥抗癌作用。

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Antitumor agent-145 Chemical Structure

Antitumor agent-145 Chemical Structure

CAS No. : 2983120-65-4

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Antitumor agent-145 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response[1].

体外研究
(In Vitro)

Antitumor agent-145 (Compound Ir5) (48h) 对 BEL-7402/DDP 细胞的 IC50 值为 0.49 μM，阻力系数(RF) 为 1.04。Antitumor agent-145 无明显细胞毒性[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-145 相关抗体:
体内研究
(In Vivo)

Antitumor agent-145 (Compound Ir5) (1.5/3.0 mg/kg，静脉注射，每隔一天，共21天) 能显著降低 BALB/c 小鼠中的肿瘤体积。Antitumor agent-145 在小鼠模型中不会引起明显的肝肾功能障碍[1].
Antitumor agent-145 (1.5/3.0 mg/kg，静脉注射， 每隔一天，共21天) 在 BEL-7402/DDP 肿瘤异种移植模型中能显著抑制CDDP耐药肿瘤的生长和转移，不导致明显组织损伤[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice
Dosage: NaCl, CDDP (3 mg/kg), Ir5 (1.5 mg/kg), and Ir5 (3 mg/kg)
Administration: every other day for 21 days
Result: The tumor volume in BALB/c mice was significantly reduced, and there was no significant difference in the weight of major organs.
Animal Model: BEL-7402/DDP tumor xenograft models
Dosage: 1.5 mg/kg or 3 mg/kg
Administration: every 2 days for 21 days
Result: The results revealed that Ir5 significantly decreases the tumor volume, with an inhibition rate of tumor growth (IRT) of 40.0% at a dose of 1.5 mg/kg and 58.1% at a dose of 3 mg/kg, compared to only 10.1% in the CDDP group. No obvious tissue injury.
分子量

873.06

Formula

C44H34IrN5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-145 相关分类

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Keywords:

Antitumor agent-1452983120-65-4Antitumor agent145Antitumor agent 145NecroptosisMitochondria-targetedcisplatin resistanceInhibitorinhibitorinhibit

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