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  4. Antitumor agent-38

Antitumor agent-38 是一种有效的抗肿瘤剂。Antitumor agent-38 在肿瘤细胞中显示抗增殖活性。 Antitumor agent-38 诱导细胞周期停滞在 S 和 G2M 晚期而不干扰微管的形成和细胞形态的变化。

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Antitumor agent-38 Chemical Structure

Antitumor agent-38 Chemical Structure

CAS No. : 2744193-34-6

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Antitumor agent-38 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.66 μM
Compound: 9h
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
KB GI50
0.76 μM
Compound: 9h
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MCF7 GI50
3.67 μM
Compound: 9h
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MDA-MB-231 GI50
0.85 μM
Compound: 9h
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
体外研究
(In Vitro)

Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 µM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].
Antitumor agent-38 (0.58, 1.74 µM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-38 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.85, 1.74 µM
Incubation Time: 24 h
Result: Cells were arrested at the late S and G2/M phase.
分子量

380.44

Formula

C22H24N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-38 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-382744193-34-6Antitumor agent38Antitumor agent 38OthersMDA-MB-231 cellsantitumorS and G2/M phasemicrotubule formationncell morphologyPhenanthrene-based tylophorine-1 (PBT-1)Inhibitorinhibitorinhibit

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