2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species
  4. Antitumor agent-57

Antitumor agent-57 (Compound 3o) 是一种 NQO1 导向的抗肿瘤剂。Antitumor agent-57 抑制肿瘤细胞生长，引发 ROS 生成，诱导细胞凋亡。

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Antitumor agent-57 Chemical Structure

Antitumor agent-57 Chemical Structure

CAS No. : 2432823-48-6

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Antitumor agent-57 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
3.13 μM
Compound: 3o
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 32464425]
A549 GI50
5.3 μM
Compound: 3o
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
[PMID: 32464425]
A549 GI50
5.48 μM
Compound: 3o
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
[PMID: 32464425]
HepG2 GI50
2.23 μM
Compound: 3o
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 32464425]
HepG2 GI50
4.93 μM
Compound: 3o
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with NQO1 inhibitor, dicoumarol followed by incubation with compound for 48 hrs by MTT assay
[PMID: 32464425]
HepG2 GI50
5.65 μM
Compound: 3o
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth pretreated for 1 hr with ROS scavenger, N-acetyl cysteine followed by incubation with compound for 48 hrs by MTT assay
[PMID: 32464425]
L02 GI50
4.36 μM
Compound: 3o
Cytotoxicity against human L02 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 32464425]
MCF7 GI50
3.06 μM
Compound: 3o
Cytotoxicity against NQO1-rich human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against NQO1-rich human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 32464425]
分子量

349.34

Formula

C20H15NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-57 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-572432823-48-6Antitumor agent57Antitumor agent 57ApoptosisReactive Oxygen SpeciesMCF-7NQO1-directed antitumor agentsHepG2A549Inhibitorinhibitorinhibit

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