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  4. Antitumor agent-67

Antitumor agent-67 (compound 3) 是一种有效的抗肿瘤剂。Antitumor agent-67 对癌细胞具有较高的选择性毒性，对正常细胞的损伤较低。Antitumor agent-67 可被 NQO1 激活，有效释放鬼臼毒素 (Podophyllotoxin)，杀死肿瘤细胞。Antitumor agent-67 在 HepG2 异种移植肿瘤模型中有明显的肿瘤抑制作用，且无明显毒性作用。

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Antitumor agent-67 Chemical Structure

Antitumor agent-67 Chemical Structure

CAS No. : 2820146-10-7

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Antitumor agent-67 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity[1].

IC50 & Target

NQO1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
100 nM
Compound: 3
Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
A549 IC50
185 nM
Compound: 3
Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
A549 IC50
197 nM
Compound: 3
Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
HepG2 IC50
113 nM
Compound: 3
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
HepG2 IC50
84 nM
Compound: 3
Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
L02 IC50
312 nM
Compound: 3
Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33091789]
体外研究
(In Vitro)

Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-67 相关抗体:
分子量

809.85

Formula

C45H47NO13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-67 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-672820146-10-7Antitumor agent67Antitumor agent 67OthersAnticancerAntiproliferativeHepG2A549LO2NQO1Inhibitorinhibitorinhibit

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