2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Antitumor agent-74

Antitumor agent-74 是一种喹唑啉衍生物和抗肿瘤试剂。Antitumor agent-74 与区域同分异构 体 Antitumor agent-75 (HY-151295, compound 14 da) (mriBIQ 13da/14da) 混合具有更强的肿瘤抑制作用。mriBIQ 13da/14da 能够抑制 DNA 合成，阻滞细胞周期在 S 期，并诱导线粒体凋亡。

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Antitumor agent-74 Chemical Structure

Antitumor agent-74 Chemical Structure

CAS No. : 2827065-28-9

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Antitumor agent-74 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75 (HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis[1].

体外研究
(In Vitro)

Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC50s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC50s=2.8-34.0 μM)[1].
mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC50 of Wi38/A549)[1].
mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-74 相关抗体:

Cell Viability Assay[1]

Cell Line: M-HeLa, MCF-7, HuTu-80, PANC-1, A549, PC3, T98G, Wi38 cells
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Showed low cytotoxicity and inhibited cancer cells with IC50s of 58.7, 67.3, 75.6, 86.3, 65.6, 63.2, 68.7, and 56.7 μM, respectively.

Cell Proliferation Assay[1]

Cell Line: A549
Concentration: mriBIQ 13da/14da: 1, 5, 25, 50, 100 μM
Incubation Time: 48 hours
Result: Decreased the rate of cell division, associated with induction of apoptosis in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549
Concentration: mriBIQ 13da/14da: 1, 2.5, 5 μM
Incubation Time: 12 hours
Result: Increased the number of cells in the S-phase at 1, 2.5, and 5 μM of 49.0%, 66.3%, and 68.0%, respectively.
分子量

438.50

Formula

C26H23FN6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-74 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-742827065-28-9Antitumor agent74Antitumor agent 74DNA/RNA Synthesislung cancercytotoxicactivitymitochondrialfluorescencemicroscopyhemolysis2-(benzimidazol-2-yl)quinoxalinesMamedov rearrangementmithochondrial apoptosisDNA synthesisattests cell cycleInhibitorinhibitorinhibit

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目录号：
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