2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-79

Antitumor agent-7 对肝细胞癌和乳腺癌细胞有良好的抗增殖活性，IC50 值为 0.7-7.9 μM。Antitumor agent-79 诱导癌细胞的凋亡，并且具有体内抗肿瘤效应。Antitumor agent-79 可用于癌症的研究。

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Antitumor agent-79 Chemical Structure

Antitumor agent-79 Chemical Structure

CAS No. : 2750233-50-0

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Antitumor agent-79 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.7 μM (Huh7), 1.4 μM (HepG2), 1.5 μM (SNU475), 7.9 μM (Hep3B), 2.4 μM (FOCUS), 5.2 μM (Hep40), 6.5 μM (PLC-PRF-5), 3.7 μM (Mahlavu), 0.9 μM (MCF7), 0.9 μM (MDA-MB231), 1.0 μM (MDA-MB468), 1.8 μM (SKBR3), 5.5 μM (ZR75), 7.6 μM (MCF10A)[1]
体外研究
(In Vitro)

Antitumor agent-79 (0.15-40 μM; 72 h) shows in vitro growth inhibitory activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM[1].
Antitumor agent-79 (5 μM; 48 h) induces cell apoptosis by increasing the PARP cleavage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-79 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Huh7, HepG2, SNU475, Hep3B, FOCUS, Hep40, PLC-PRF-5, Mahlavu, MCF7, MDA-MB231. MDA-MB468, SKBR3, ZR75 and MCF10A cell lines
Concentration: 0.15-40 μM
Incubation Time: 72 hours
Result: Time and dose-dependent showed cytotoxicity to hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7, 1.4, 1.5, 7.9, 2.4, 5.2, 6.5, 3.7, 0.9, 0.9, 1.0, 1.8, 5.5 and 7.6 μM for Huh7, HepG2, SNU475, Hep3B, FOCUS, Hep40, PLC-PRF-5, Mahlavu, MCF7, MDA-MB231, MDA-MB468, SKBR3, ZR75 and MCF10A cells, respectively.

Western Blot Analysis[1]

Cell Line: Mahlavu, Huh7, MCF-7 and MDA-MB-231 cancer cells
Concentration: 5 μM
Incubation Time: 48 hours
Result: Increased the PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu).

Apoptosis Analysis[1]

Cell Line: Mahlavu, Huh7, MCF-7 and MDA-MB-231 cancer cells
Concentration: 5 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis of cancer cells.
体内研究
(In Vivo)

Antitumor agent-79 (40 mg/kg; p.o. twice a week for 4 weeks) shows antitumor effects in mice xenograft models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6−8 weeks old male athymic nude mice with hepatocellular carcinoma (Mahlavu cells) and breast (MDA MB-231 cells) xenografts[1]
Dosage: 40 mg/kg
Administration: Oral gavage; 40 mg/kg; twice a week for 4 weeks
Result: Significantly reduced the tumor volume following 4 weeks treatment with 40% reductions of tumor volumes in the Mahlavu xenografts. Resulted in about a 50% decreased in tumor volumes as compared to the control group in MDA-MB-231 xenografts. Showed well tolerated in vivo and neither significant bodyweight loss nor toxic effects or mortality were observed.
分子量

374.86

Formula

C23H19ClN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-79 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-792750233-50-0Antitumor agent79Antitumor agent 79ApoptosisisoxazolepyrazolederivativeantiproliferativeantitumorapoptosiscancerInhibitorinhibitorinhibit

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