2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-92

Antitumor agent-92 是一种淫羊藿素 (HY-N0678) 衍生物，可导致细胞周期停滞在 G0/G1 期，并诱导细胞凋亡。Antitumor agent-92 具有用于肝细胞癌 (HCC) 研究的潜力。

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Antitumor agent-92 Chemical Structure

Antitumor agent-92 Chemical Structure

CAS No. : 2922842-01-9

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Antitumor agent-92 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research[1].

体外研究
(In Vitro)

Antitumor agent-92 (化合物 11c; 2-8 μM; 48 小时) 诱导 HepG2 和 SMMC-7721 细胞凋亡，特别是在高浓度时[1]。
Antitumor agent-92 (2-8 μM; 48 小时) 可以在 HepG2 和 SMMC-7721 细胞中诱导 G0/G1 周期停滞[1]。
Antitumor agent-92 (2-8 μM; 48 小时) 上调 P21 并下调 Cdc2 p34 和 CDK4[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-92 相关抗体:

Apoptosis Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.

Western Blot Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.
分子量

611.68

Formula

C33H41NO10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-92 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-922922842-01-9Antitumor agent92Antitumor agent 92ApoptosisIcaritinG0/G1cell cycleHepG2SMMC-7721hepatocellular carcinoma (HCC)Inhibitorinhibitorinhibit

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