1. Apoptosis
  2. Apoptosis
  3. Apoptosis inducer 12

Apoptosis inducer 12 (Compound 3z) 是一种通过线粒体途径诱导凋亡 (apoptosis) 的凋亡诱导剂,可用于癌症的研究。

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Apoptosis inducer 12 Chemical Structure

Apoptosis inducer 12 Chemical Structure

CAS No. : 1971096-01-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer[1].

体外研究
(In Vitro)

Apoptosis inducer 12 (Compound 3z; 72 h) 对 9 种人类肿瘤细胞 (白血病、非小细胞肺癌、结肠癌、中枢神经系统、黑色素瘤、卵巢癌、肾癌、前列腺癌和乳腺癌) 具有抗增殖活性,GI50 为 0.24-96.6 μM。白血病和前列腺细胞系对 Apoptosis inducer 12 的反应特别明显,GI50 值分别为 0.30-0.65 μM 和 0.43-0.84 μM [1]
Apoptosis inducer 12 (0.5-10 μM; 24 h) 阻断 A549、CCRF-CEM 和 VL51 细胞的中期细胞周期[1]
Apoptosis inducer 12 (0.5-5 μM; 48 h) 诱导 A549、CCRF-CEM 和 VL51 细胞凋亡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: A549, CCRF-CEM and VL51
Concentration: 0.5, 1, 5 and 10 μM
Incubation Time: 24 h
Result: Induced a block in G2/M accompanied by a strong decrease in S phase cells.

Apoptosis Analysis[1]

Cell Line: A549, CCRF-CEM and VL51
Concentration: 0.5, 1 and 5 μM
Incubation Time: 48 h
Result: Induced massive apoptosis in a dose-dependent manner.
分子量

475.54

Formula

C27H29N3O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Apoptosis inducer 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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