2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 20

Apoptosis inducer 20 (12) 导致 G2/M 细胞周期阻滞，并通过 caspase 3/7 激活诱导细胞凋亡 (apoptosis)，这发生在 M 阻滞期间。Apoptosis inducer 20 是一种新型的吲哚类苯磺酰胺，对多种癌细胞具有抗增殖作用，有望用于新的抗有丝分裂药物的研究。

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Apoptosis inducer 20 Chemical Structure

Apoptosis inducer 20 Chemical Structure

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Apoptosis inducer 20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents[1].

体外研究
(In Vitro)

Apoptosis inducer 20 抑制不同癌细胞系的细胞生长活性。最敏感的细胞系是黑色素瘤细胞系 MelMet5，紧随其后的是 HeLa。[1]。
Apoptosis inducer 20 (100 nM, 24 h) 导致 G2/M 细胞周期阻滞，并通过 caspase 3/7 激活诱导细胞凋亡[1]。

活性磺胺类化合物对 HeLa, MCF7, BT-474, MDA-MB468, MES-SA, HT-1080, MelMet5, A375、WM-1366 和 Caki1 癌细胞的抗增殖 IC50 值[1]

药代动力学分析[1]

HeLa MCF7 BT-474 MDA-MB468 MES-SA HT-1080 MelMet5 A375 WM-1366 Caki1
12 11.0 13.7 68.3 13.0 8.9 9.9 8.9 22.1 52.8 56.2

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 20 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 100 nM
Incubation Time: 24 h
Result: Increased the percentage of cells in the G2/M ensemble from 13.3 % to 83.6-89.7 % at the expense of the S (from 27 % to 6-9 %) and G1 phases (from 60 % to 4-7 %) in MES-SA cells.

Apoptosis Analysis[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 100 nM
Incubation Time: 3 days
Result: Induced caspase activation and therefore cell apoptosis in a time-dependent manner in MES-SA cells.

Immunofluorescence[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 10 nM
Incubation Time: 24 h
Result: Induced microtubule nonfunction, depolymerization and the cell loseed its characteristic shape in MES-SA cells.
分子量

415.46

Formula

C20H21N3O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 20 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 20Apoptosis inducer20Apoptosis inducer-20ApoptosisG2/M cell cyclecaspase 3/7 activationindolic benzenesulfonamidecancer cell linesanti-mitoticInhibitorinhibitorinhibit

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