2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24) 5-HT Receptor
  4. ATC0065

ATC0065 是一种强效，选择性的且具有口服活性的的黑色素浓缩激素 (MCH) 受体 1 (MCHR1) 拮抗剂，对人类 MCHR1 的 IC50 为 15.7 nM。ATC0065 对 MCHR2 没有表现出显著的活性。ATC0065 具有抗焦虑和抗抑郁作用。

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ATC0065 Chemical Structure

ATC0065 Chemical Structure

CAS No. : 510732-84-0

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规格 价格 是否有货 数量
5 mg ￥1150
1 - 2 周
10 mg ￥1900
1 - 2 周
25 mg ￥4000
1 - 2 周
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of ATC0065:

ATC0065 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities[1].

体外研究
(In Vitro)

ATC0065 对 5-HT2B 和 5-HT1A 受体也表现出高至中等亲和力，IC50 值分别为 266 nM 和 62.9 nM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATC0065 相关抗体:
体内研究
(In Vivo)

ATC0065（3-30 mg/kg；口服；试验前 3 小时）在大鼠中表现出抗抑郁样作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SpragueDawley rats (190-250 g) forced swimming[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Oral administration; 3 h prior to the test
Result: Significantly reduced immobility time in the forced swimming.
分子量

625.35

Formula

C25H31BrCl2F3N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATC0065 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATC0065510732-84-0ATC 0065ATC-0065MCHR1 (GPR24)5-HT ReceptorMelanin concentrating hormone receptor 1Serotonin Receptor5-hydroxytryptamine ReceptorMCHR1 antagonistanxiolytic and antidepressant activitiesorally activeInhibitorinhibitorinhibit

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产品名称：
ATC0065
目录号：
HY-107626
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