Atorvastatin sodium 

Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively^{[1][2][3][4][5]}.

Atorvastatin sodium 通过下调心肌梗死后心肌细胞中 GRP78、caspase-12 和 CHOP 的表达来减少心肌细胞凋亡，并响应心力衰竭和血管紧张素 II (Ang II) 刺激而激活内质网 (ER) 应激< sup>[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Atorvastatin（20-30 mg/kg；口服灌胃；每天一次；持续 28 天；ApoE^−/− 小鼠）sodium 显着降低内质网 (ER) 应激信号蛋白、凋亡细胞数量，以及 Ang II 诱导的 ApoE-/- 小鼠中 Caspase12 和 Bax 的激活。Atorvastatin sodium 治疗后，IL-6、IL-8、IL-1β 等促炎细胞因子均受到显着抑制^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

580.62

C₃₃H₃₄FN₂NaO₅

134523-01-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Br J Pharmacol. 2006 Sep;149(1):14-22.  [Content Brief]

  [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.  [Content Brief]

  [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.  [Content Brief]

  [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.  [Content Brief]

  [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.  [Content Brief]

  [6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.  [Content Brief]