2. Autophagy
  3. Autophagy
  4. Autophagonizer

Autophagonizer (DK-1-49) 是一种小分子自噬 (autophagy) 诱导剂，导致自噬相关的 LC3-II 积累，并增加自噬体和酸性液泡的水平。Autophagonizer 不仅在癌细胞中，还能在 Bax/Bak 双敲除的细胞中抑制细胞的活力，诱导细胞死亡，其 EC50 值为 3-4 μM。

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Autophagonizer Chemical Structure

Autophagonizer Chemical Structure

CAS No. : 853136-76-2

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Autophagonizer 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC50 values of 3-4 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
1.3 μM
Compound: DK-1-49
Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay
Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay
[PMID: 27597252]
HeLa EC50
3.5 μM
Compound: DK-1-49
Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay
Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay
[PMID: 27597252]
HeLa EC50
3.5 μM
Compound: DK-1-49
Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay
Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay
[PMID: 27597252]
MEF EC50
2.1 μM
Compound: DK-1-49
Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay
Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay
[PMID: 27597252]
MEF EC50
2.2 μM
Compound: DK-1-49
Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay
Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay
[PMID: 27597252]
分子量

549.71

Formula

C28H31N5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Autophagonizer 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagonizer853136-76-2DK-1-49Autophagyautophagy inducerLC3-IIautophagosomesacidic vacuolescell viabilitycell deathcancer cellsBax/Bak double-knockout cellsInhibitorinhibitorinhibit

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