1. Immunology/Inflammation
  2. Complement System
  3. Avdoralimab

Avdoralimab  (Synonyms: 艾朵利单抗; IPH 5401; Anti-C5aR1 mAb)

目录号: HY-P99450 纯度: 95.16%
COA

Avdoralimab (IPH 5401) 是一种全人 IgGκ 单克隆抗体,靶向补体 C5a 受体 1 (C5aR1),阻止其与 C5a 结合。Avdoralimab 可用于补体驱动的炎症性疾病和实体瘤研究。

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CAS No. : 2226393-85-5

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg ¥7800
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50 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research[1].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

Avdoralimab (IPH 5401) 选择性阻断人骨髓细胞中的 C5a-C5aR1 相互作用及其下游信号传导。在体外,用 Avdoralimab (10-30 μg/mL) 阻断 C5aR1 可抑制 C5a 诱导的中性粒细胞活化。Avdoralimab 阻断由非常高浓度的 C5a 诱导的嗜中性粒细胞活化。Avdoralimab 还在体外抑制 C5a 诱导的中性粒细胞迁移[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在敲入人类 C5aR1 的小鼠(HuC5aR1 KI 小鼠)中,Avdoralimab 阻断嗜中性粒细胞和单核细胞的浸润,阻止白蛋白在支气管肺泡灌洗液 (BALF) 中的释放,并限制 C5a 诱导的急性肺损伤 (ALI) 组织病理学特征[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾朵利单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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