2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor c-Met/HGFR
  4. Axl-IN-8

Axl-IN-8 (NO.1) 是一种有效的 AXL 抑制剂，其 IC50 低于 1 nM。Axl-IN-8 也抑制 c-MET，IC50 在 1-10 nM 之间。Axl-IN-8 对 BaF3/TEL-AXL、MKN45 和 EBC-1 细胞均有抗增殖活性，其 IC50 值分别为 <10、226.6 和 120.3 nM。

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Axl-IN-8 Chemical Structure

Axl-IN-8 Chemical Structure

CAS No. : 2231424-62-5

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Axl-IN-8 相关抗体

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Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].

IC50 & Target

Axl

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BaF3 IC50
< 1 nM
Compound: 9g
Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
[PMID: 33957388]
MKN-45 IC50
247.9 nM
Compound: 9g
Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
[PMID: 33957388]
分子量

552.60

Formula

C31H29FN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Axl-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Axl-IN-82231424-62-5TAM Receptorc-Met/HGFRTyro3AxlMerSNU-886 cellsBaF3/TEL-AXLMKN45EBC-1 cellsCancerInhibitorinhibitorinhibit

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