2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Bcr-Abl Apoptosis
  4. AZD0424

AZD0424 是选择性 Src/Abl 激酶抑制剂，可口服，具有抗肿瘤活性。AZD0424 可以诱导淋巴瘤细胞凋亡 (apoptosis) 和细胞周期停滞。

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AZD0424 Chemical Structure

AZD0424 Chemical Structure

CAS No. : 692054-06-1

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AZD0424 相关抗体

Top Publications Citing Use of Products

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2].

IC50 & Target

Src/Abl kinase inhibitor (SrcK-I), apoptosis[1]
体外研究
(In Vitro)

AZD0424 (1-5 μM; 24-48 hours) is emerged to be the more effective of the three tested inhibitors (AZM559756, AZD0530 and AZD0424), inducing the highest levels of apoptosis with the lowest concentrations in lymphoma cells[2].
AZD0424 (5 μM; 48 hours) leads to increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells, whereas the cell cycle progression of the nonsensitive cell lines Raji and Jurkat remains unaffected[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZD0424 相关抗体:

Apoptosis Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji, Jurkat, Karpas-299 and HUT78 cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 24 hours, 48 hours
Result: Induced apoptosis in lymphoma cells.

Cell Cycle Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji and Jurkat cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 48 hours
Result: Increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells.
Clinical Trial
分子量

528.99

Formula

C25H29ClN6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZD0424 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD0424692054-06-1AZD 0424AZD-0424SrcBcr-AblApoptosisInhibitorinhibitorinhibit

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目录号：
HY-112314
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