2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. Raf VEGFR FGFR
  4. B-Raf IN 17

B-Raf IN 17 (Compound 8e) 是一种有效的、具有口服活性的 II 型多激酶 抑制剂。B-Raf IN 17 在 A375 细胞系中表现出对 BRAFWT、VEGFR-2 和 FGFR-1 的有效细胞水平抑制，IC50 值分别为 0.02、0.18 和 1.65μM。B-Raf IN 17 可用于癌症研究。

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B-Raf IN 17 Chemical Structure

B-Raf IN 17 Chemical Structure

1.  客户无需承担相应的运输费用。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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B-Raf IN 17 相关抗体

Top Publications Citing Use of Products

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BRaf c-Raf Raf

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

B-Raf IN 17 (Compound 8e) is a potent and orally active type II multi-kinase inhibitor. B-Raf IN 17 exhibits potent cellular-level suppression of BRAFWT, VEGFR-2, and FGFR-1 in A375 cell line, with IC50 values of 0.02, 0.18 and 1.65 μM, respectively. B-Raf IN 17 can be used for the research of cancer[1].
体内研究
(In Vivo)

B-Raf IN 17 (10-20mg/kg，口服，每周 3 次，持续 21 天) 可抑制携带 B16F10 细胞的 C57BL/6 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice bearing B16F10 cells
Dosage: 10-20mg/kg
Administration: p.o., three time pre week for 21 days
Result: Prolonged the overall survival time.
Reduced angiogenesis markers, mRNA expression levels of VEGFR-2 and FGFR-1, and production of growth factors.
Downregulated Notch1 protein expression and decreased TGF-β1 production.
分子量

460.28

Formula

C22H14BrN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

B-Raf IN 17 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

B-Raf IN 17RafVEGFRFGFRRaf kinasesVascular endothelial growth factor receptorFibroblast growth factor receptorA375cancerB16F10C57BL/6Inhibitorinhibitorinhibit

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