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  4. Bapotulimab

Bapotulimab  (Synonyms: 巴泊妥利单抗; BAY-1905254)

目录号: HY-P99460 纯度: 95.00%
COA

Bapotulimab (BAY-1905254) 是一种全人 IgG2 抗体,靶向含有免疫球蛋白样结构域的受体 2 (ILDR2)。Bapotulimab 具有抗肿瘤和免疫抑制作用。

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CAS No. : 2359413-58-2

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规格 价格 是否有货 数量
1 mg ¥4600
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects[1].

同型

Human IgG2 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

Bapotulimab 阻断 ILDR2 对 T 细胞活化的免疫抑制作用。Bapotulimab 具有小鼠/人交叉反应性,因为 ILDR2 在人和鼠直系同源物的细胞外结构域之间具有 98% 的序列同一性[1]
Bapotulimab (BAY-1905254;5、25、100 或 500 ng/mL) 在体外促进 T 细胞活化并增强抗原特异性 T 细胞增殖[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Bapotulimab(BAY-1905254;10 mg/kg;腹腔注射;在第 1 天和第 4 天)显示抗原特异性 T 细胞增殖和细胞毒性显着增加[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells[1]
Dosage: 10 mg/kg
Administration: i.p.; on days 1 and 4
Result: Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

巴泊妥利单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG2 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-P99460
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