2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. BCR-ABL-IN-5

BCR-ABL-IN-5 (compound II) 是一种 Bcr-Abl (Breakpoint cluster region-Abelson) 激酶抑制剂，其对 Bcr-AblWT 和 Bcr-AblT3151 的 IC50 值分别为 0.014 μM, 0.45 μM。BCR-ABL-IN-5 具有一定的抗白血病细胞增殖活性。

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BCR-ABL-IN-5 Chemical Structure

BCR-ABL-IN-5 Chemical Structure

CAS No. : 1795736-60-5

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BCR-ABL-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1].

IC50 & Target

IC50: 6.5 μM (K562)[1].
体外研究
(In Vitro)

BCR-ABL-IN-5 (compound II) (0-100 mM, 72 hours) can inhibit the proliferation of K562 human leukemia cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BCR-ABL-IN-5 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562 human leukemia cell line
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited K562 proliferation with an IC50 value of 6.5 μM.
分子量

494.37

Formula

C25H21Cl2N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BCR-ABL-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCR-ABL-IN-51795736-60-5Bcr-AblBcr-Abl kinase inhibitorBcr-AblT315IleukemiccancerK562 cell linesInhibitorinhibitorinhibit

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目录号：
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