Befloxatone  (Synonyms: MD-370503)

Befloxatone (MD-370503) is an orally active, selective and reversible inhibitor of Monoamine Oxidase A (MAO-A) (IC₅₀=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential^[1].

Befloxatone (100 nM; 0-100 min) 可逆抑制大鼠脑匀浆中的 MAO-A 活性，60 min 后不再发挥抑制作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Befloxatone (0.75 mg/kg; i.p.; single dose) 在大鼠中增加单胺的组织水平，并降低其脱氨基代谢物的水平^[1]。
Befloxatone (1 mg/kg; i.p.; single dose) 可诱导大鼠细胞外纹状体多巴胺和皮质去甲肾上腺素水平升高，但不诱导皮质 5-羟色胺水平升高^[1]。
Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) 在大鼠中有效抑制血清素能神经元的放电速率，部分降低去甲肾上腺素能神经元的发射，对多巴胺能神经元的激发没有影响^[1]。
Befloxatone (1.5 mg/kg; p.o.; single dose) 在大鼠中不会增强中心活性剂量口服酪胺的升压作用，具有广泛的安全性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

349.30

C₁₅H₁₈F₃NO₅

134564-82-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Curet O, et al. Preclinical profile of befloxatone, a new reversible MAO-A inhibitor. J Affect Disord. 1998 Dec;51(3):287-303.  [Content Brief]