2. Immunology/Inflammation Apoptosis
  3. Galectin Apoptosis
  4. Belapectin

Belapectin  (Synonyms: GR-MD-02)

目录号: HY-114440 纯度: 99.33%
COA 产品使用指南

摩尔计算器

Belapectin (GR-MD-02) 是一种半乳凝素-3 (Gal-3) 抑制剂。Belapectin 通过诱导 T 细胞凋亡 (Apoptosis) 来驱动肿瘤诱导的免疫抑制。Belapectin 通过 CD8+ T 细胞依赖机制，促进肿瘤消退并提高荷瘤小鼠生存率。Belapectin 结合 Gal-3 的 Ki 为 2.8 μM。

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Belapectin Chemical Structure

Belapectin Chemical Structure

CAS No. : 1980787-47-0

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1 mg ￥8000
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Belapectin 相关抗体

Top Publications Citing Use of Products

查看 Galectin 亚型特异性产品:

查看所有亚型
Galectin-1 Galectin-3 Galectin-4 Galectin-8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2].

IC50 & Target

Galectin-3

 

体外研究
(In Vitro)

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖，诱导凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belapectin 相关抗体:

Apoptosis Analysis[1]

Cell Line: TRAMP-C1, 4T1 and MCA-205 cells
Concentration: 0.2 mg/mL, 2 mg/mL
Incubation Time: 48 h
Result: Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.
体内研究
(In Vivo)

Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后，才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆，100% 无瘤小鼠被保护免于随后的肿瘤再攻击[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL/6 and BALB/c mice[1]
Dosage: 2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg)
Administration: Intraperitoneal injection; 3 times per week for 3 weeks
Result: Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.33%

COA (283 KB) HNMR (194 KB) RP-HPLC (1350 KB)

产品使用指南 (1538 KB)
参考文献

Belapectin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belapectin1980787-47-0GR-MD-02GalectinApoptosisInhibitorinhibitorinhibit

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