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Betulinic acid derivative-1 在抑制破骨细胞（OC）分化方面表现出显著的活性，IC50 值为 1.86 μM。

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Betulinic acid derivative-1 Chemical Structure

Betulinic acid derivative-1 Chemical Structure

CAS No. : 2708127-92-6

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Betulinic acid derivative-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC50 value of 1.86 μM.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
1.86 μM
Compound: 25
Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay
Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay
[PMID: 34491054]
RAW264.7 CC50
16.18 μM
Compound: 25
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 34491054]
RAW264.7 IC50
2.32 μM
Compound: 25
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis
[PMID: 34491054]
RAW264.7 IC50
21.41 μM
Compound: 25
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis
[PMID: 34491054]
RAW264.7 CC50
5.77 μM
Compound: 25
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay
[PMID: 34491054]
RAW264.7 IC50
8.1 μM
Compound: 25
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis
[PMID: 34491054]
分子量

560.90

Formula

C37H60N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Betulinic acid derivative-1 相关分类

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betulinic acid derivative-12708127-92-6Betulinic acid derivative1Betulinic acid derivative 1OthersInhibitorinhibitorinhibit

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目录号：
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