2. Immunology/Inflammation
  3. STING
  4. BI 7446

BI 7446 是一种基于环状二核苷酸 (CDN) 的强效、选择性干扰素基因刺激蛋白 (STING) 激动剂。BI 7446 能激活细胞中所有五种 STING 变体，在体外能诱导肿瘤特异性免疫介导的肿瘤排斥反应。BI 7446 可用于免疫肿瘤学的研究。

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BI 7446 Chemical Structure

BI 7446 Chemical Structure

CAS No. : 2767011-00-5

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BI 7446 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research[1].

体外研究
(In Vitro)

BI 7446 (CDN13) (3 μM, 10 μM, 6 小时) 增加 THP1 STING - 野生型细胞中 IRF3 和 TBK1 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BI 7446 相关抗体:

Western Blot Analysis[1]

Cell Line: wild type and STING-knock out THP1 cells
Concentration: 3 μM, 10 μM
Incubation Time: 6 h
Result: Observed a dose dependent increase of IRF3 and TBK1 phosphorylation in THP1 wild type cells but not in THP1 STING knockout cells.
体内研究
(In Vivo)

BI 7446 (CDN13) (4, 12, 36 μg, 静脉注射, 0-25 h 检测时间点) 在 4T1 肿瘤小鼠模型中血浆清除率高，消除半衰期短[1]。
BI 7446 (0.25, 1, 4 μg, 皮下注射, 每周一次) 在 EMT 乳腺癌模型小鼠中产生肿瘤消退，并对自体肿瘤再攻击产生长期的免疫记忆[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 BALB/c mouse tumor model [1]
Dosage: 4, 12, 36 μg
Administration: Intravenous injection (i.v.)
Result: Observed a high plasma clearance and a short elimination half-life.
Animal Model: EMT6 mouse breast cancer model[1]
Dosage: 0.25, 1, 4 μg
Administration: Subcutaneous injection (s.c.)
Result: Observed dose-dependent tumor regression even at the lowest tested dose.
Impaired the growth of the EMT6 tumors.
分子量

693.52

Formula

C20H22FN9O10P2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BI 7446 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 74462767011-00-5BI7446BI-7446STINGStimulator of Interferon GenesTMEM173MITAERISMPYScancerimmune systemInhibitorinhibitorinhibit

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