2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Bifidenone

Bifidenone 是一种微管聚合 (tubulin polymerization) 抑制剂，对多种人类癌细胞系表现出抗增殖活性。

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Bifidenone Chemical Structure

Bifidenone Chemical Structure

CAS No. : 2078008-57-6

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Bifidenone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
0.075 μM
Compound: 2
Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
ACHN IC50
0.36 μM
Compound: 2
Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
HCC 2998 IC50
1.41 μM
Compound: 2
Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay
Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay
[PMID: 28335606]
M14 IC50
0.064 μM
Compound: 2
Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
M14 IC50
0.11 μM
Compound: 4a
Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay
Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay
[PMID: 29995409]
Malme-3M IC50
< 0.1 μM
Compound: 2
Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay
Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay
[PMID: 28335606]
MDA-MB-435 IC50
< 0.1 μM
Compound: 2
Antiproliferative activity against human MDA-MB-435 cells after SRB assay
Antiproliferative activity against human MDA-MB-435 cells after SRB assay
[PMID: 28335606]
NCI/ADR-RES IC50
0.17 μM
Compound: 2
Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay
Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay
[PMID: 28335606]
NCI-H460 IC50
0.26 μM
Compound: 4a
Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay
[PMID: 29995409]
NCI-H460 IC50
0.26 μM
Compound: 2
Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
PC-3 IC50
0.49 μM
Compound: 2
Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
RAW264.7 IC50
> 5 μM
Compound: 2
Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
SF-295 IC50
0.25 μM
Compound: 2
Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
SK-MEL-2 IC50
0.095 μM
Compound: 2
Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
SR IC50
< 0.1 μM
Compound: 2
Antiproliferative activity against human SR cells after 48 hrs by SRB assay
Antiproliferative activity against human SR cells after 48 hrs by SRB assay
[PMID: 28335606]
UACC-62 IC50
0.044 μM
Compound: 2
Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay
[PMID: 28335606]
分子量

358.43

Formula

C21H26O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bifidenone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bifidenone2078008-57-6Microtubule/Tubulintubulin polymerizationantiproliferativecancer cell linesInhibitorinhibitorinhibit

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