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  2. Calcitonin gene-related peptide (CGRP)

Calcitonin gene-related peptide (CGRP)降钙素基因相关肽

释义:

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality. CGRP is a highly potent vasodilator and, partly as a consequence, possesses protective mechanisms that are important for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and thus is implicated in pain pathways.

降钙素基因相关肽 (CGRP) 是一种由 37 个氨基酸组成的神经肽,是降钙素基因的 RNA 替代加工的结果。CGRP 有两种主要形式 (α 和 β)。它属于一组肽,都作用于一个不寻常的受体家族。这些受体包括降钙素受体样受体(CLR),它与基本受体活性修饰蛋白( RAMP) 相连接,而 RAMP 是完全功能所必需的。CGRP 是一种高效的血管扩张剂,因此,它具有保护机制,对心血管系统和伤口愈合等生理和病理条件非常重要。CGRP 主要由感觉神经释放,因此与疼痛通路有关。

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