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  3. Immune checkpoint molecules

Immune checkpoint molecules免疫检查点分子

释义：

Immune checkpoint molecules, including inhibitory and stimulatory immune checkpoint molecules, are defined as ligand-receptor pairs that exert inhibitory or stimulatory effects on immune responses.  Most of the immune checkpoint molecules that have been described so far are expressed on cells of the adaptive immune system, particularly on T cells, and of the innate immune system.     They are crucial for maintaining the self-tolerance and modulating the length and magnitude of immune responses of effectors in different tissues to minimize the tissue damage.  There are some common tumor cell-associated immune checkpoint molecules, such as PD-L1, PD-1, B7-H3, B7-H4, LILRB1, LILRB2, TIM3, CD47, CD137, and CD70.

免疫检查点分子包括抑制性和刺激性免疫检查点分子，是对免疫应答发挥抑制或刺激作用的配体-受体对。目前所描述的大多数免疫检查点分子表达于适应性免疫系统的细胞，特别是T细胞和固有免疫系统。它们对于维持机体自身耐受、调节不同组织中效应器免疫应答的长度和强度以减少组织损伤至关重要。常见的肿瘤细胞相关免疫检查点分子有PD-L1、PD-1、B7-H3、B7-H4、LILRB1、LILRB2、TIM3、CD47、CD137、CD70等。

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