2. Inhibitory Antibodies
  3. Blosozumab

Blosozumab  (Synonyms: 布索组单抗)

目录号: HY-P99186 纯度: 98.20%
COA

摩尔计算器

Blosozumab (LY2541546) 是一种抗人 sclerostin (SOST) 的抗体抑制剂。Blosozumab 可刺激骨形成并减少骨吸收。Blosozumab 可用于骨质疏松症的研究。

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CAS No. : 1132758-87-2

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9000
In-stock
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50 mg   询价  

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Blosozumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

sclerostin (SOST)[1]
体内研究
(In Vivo)

Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats [2]
Dosage: 1, 10, and 100 mg/kg
Administration: Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
Result: Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

布索组单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料
参考文献

Blosozumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blosozumab1132758-87-2布索组单抗OthersOsteoporosissclerostinplateletsbone formationbone resorptionInhibitorinhibitorinhibit

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