2. Neuronal Signaling Cell Cycle/DNA Damage
  3. AAK1 Cyclin G-associated Kinase (GAK)
  4. BMT-090605

BMT-090605 是一种有效的选择性连接蛋白-2 相关激酶 1 (AAK1) 抑制剂，IC50 值为 0.6 nM。BMT-090605 显示抗伤害活性。BMT-090605 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 GAK，IC50 值分别为 45 nM 和 60 nM。BMT-090605 可用于神经性疼痛的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 BMT-090605 hydrochloride 通常具有更好的水溶性和稳定性。

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BMT-090605 Chemical Structure

BMT-090605 Chemical Structure

CAS No. : 1551403-51-0

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BMT-090605 的其他形式现货产品:

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BMT-090605 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain[1].

IC50 & Target

IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
体外研究
(In Vitro)

BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMT-090605 相关抗体:
体内研究
(In Vivo)

BMT-090605 (intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1]
Dosage: 0.3-3 µg/rat
Administration: Intrathecal
Result: Caused a dose-dependent reduction in thermal hyperalgesia.
分子量

364.44

Formula

C21H24N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMT-090605 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMT-0906051551403-51-0BMT090605BMT 090605AAK1Cyclin G-associated Kinase (GAK)Adaptor-associated Kinase 1AP2-associated kinase 1Auxilin 2adapter protein-2 associated kinase 1 (AAK1)neuropathicpainchronicconstrictioninjuryCCIBMP-2-inducible protein kinase (BIKE)Cyclin G-associated kinase (GAK)Inhibitorinhibitorinhibit

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