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BN201 在体外可促进神经元分化，促进前体细胞向成熟少突胶质细胞的分化 (EC50 为 6.3 μM) 和 新轴突的髓鞘化 (EC50 为 16.6 μM)。BN201 能够通过主动穿越血脑屏障，并激活与应激和神经元存活反应相关的途径 (如 IGF-1 途径)，具有有效的神经保护作用。

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BN201 Chemical Structure

BN201 Chemical Structure

CAS No. : 1361200-34-1

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BN201 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects[1].

体外研究
(In Vitro)

BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1].
BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BN201 相关抗体:

Western Blot Analysis[1]

Cell Line: Hela cells
Concentration: 10 μM
Incubation Time: 0.5 hour, 1 hour, 4 hours
Result: Induced the phosphorylation of NDGR1 in Hela cells in a dose- and time-dependent manner.
体内研究
(In Vivo)

BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment displays less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (8-12 weeks old) by immunization with MOG35-55 (experimental autoimmune encephalitis , EAE)[1]
Dosage: 12.5 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg, 150 mg/kg
Administration: Intraperitoneal injection; daily; for 30 days
Result: Displayed less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.
Clinical Trial
分子量

491.60

Formula

C25H38FN5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BN201 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BN2011361200-34-1BN 201BN-201OthersNeuroprotectiveneuronsmyelin-formingdifferentiationNDGR1multiplesclerosisBBBopticneuritisIGF-1Inhibitorinhibitorinhibit

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