2. PROTAC
  3. PROTAC Linkers
  4. Boc-11-aminoundecanoic acid

Boc-11-aminoundecanoic acid 

目录号: HY-W013253 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Boc-11-aminoundecanoic acid 是基于 Alkyl/ether 结构的 PROTAC linker, 可以用来制备 MS432 (HY-130602)。

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Boc-11-aminoundecanoic acid Chemical Structure

Boc-11-aminoundecanoic acid Chemical Structure

CAS No. : 10436-25-6

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Boc-11-aminoundecanoic acid 相关抗体

Top Publications Citing Use of Products

查看 PROTAC Linkers 亚型特异性产品:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-11-aminoundecanoic acid 相关抗体:
分子量

301.42

Formula

C16H31NO4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (256 KB) HNMR (119 KB)

产品使用指南 (1538 KB)
参考文献

Boc-11-aminoundecanoic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-11-aminoundecanoic acid10436-25-6PROTAC LinkersMS432protaclinkercancerInhibitorinhibitorinhibit

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目录号：
HY-W013253
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