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  4. BP13944

BP13944是一种通过高通量筛选发现的潜在小分子抑制剂。它能有效抑制登革热病毒(DENV)复制子的表达，EC50值为1.03±0.09 μM。BP13944可以抑制所有四种血清型DENV的复制或病毒RNA合成，但对日本脑炎病毒无效。BP13944可能以DENV NS3蛋白酶为靶点，对NS3蛋白酶区域的E66G氨基酸替换会导致病毒对BP13944产生抗性。BP13944没有明显的细胞毒性。由于目前还没有有效的登革热疫苗和抑制方法，BP13944作为一种有效的小分子抑制剂，未来可能成为抑制登革热的潜在试剂。

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BP13944 Chemical Structure

BP13944 Chemical Structure

CAS No. : 1622060-51-8

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BP13944 相关抗体

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生物活性

BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.

分子量

410.47

Formula

C20H44BrNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BP13944 相关分类

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Keywords:

BP139441622060-51-8BP 13944BP-13944OthersInhibitorinhibitorinhibit

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