2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 D1-IN-2

BRD4 D1-IN-2 (compound 26) 是一种有效的选择性 BRD4 D1 抑制剂 (IC50<0.092 µM)。BRD4 D1-IN-2 对 BRD4 D1 具有 15 nM 亲和力，对 BRD2 D1 和 BRD4 D2 具有 500 倍以上的选择性。

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BRD4 D1-IN-2 Chemical Structure

BRD4 D1-IN-2 Chemical Structure

CAS No. : 2863687-22-1

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BRD4 D1-IN-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC[1].

IC50 & Target[1]

BRD4 BD1

<0.092 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 EC50
3.6 μM
Compound: 26
Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
[PMID: 35007061]
分子量

592.70

Formula

C33H39F3N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 D1-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 D1-IN-22863687-22-1Epigenetic Reader DomainBET bromodomainselectivehigh affinityMM.1S cellsInhibitorinhibitorinhibit

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目录号：
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