2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRPF1B/TRIM24-IN-1

BRPF1B/TRIM24-IN-1 (compound 34) 是一种有效的 TRIM24/BRPF1/BRPF2 抑制剂，其 IC50 值分别为 0.43、0.34、1.75 μM。BRPF1B/TRIM24-IN-1 与 TRIM24 溴结构域结合的 KD 为 222 nM，与 BRPF1 溴结构域的 KD 为 137 nM，与 BRD1 的 KD 为 1130 nM。

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BRPF1B/TRIM24-IN-1 Chemical Structure

BRPF1B/TRIM24-IN-1 Chemical Structure

CAS No. : 1242907-48-7

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BRPF1B/TRIM24-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].

IC50 & Target

BRPF1

0.34 μM (IC50)

BRPF2

1.75 μM (IC50)

体外研究
(In Vitro)

BRPF1B/TRIM24-IN-1 (compound 34) 在乳腺癌细胞系 MCF-7 中没有表现出明显的细胞毒性。BRPF1B/TRIM24-IN-1 对一组癌细胞系 (MM1S、RCH-ACH、JJN3、RKO) 具有适度的细胞毒性 (GI50 > 10 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRPF1B/TRIM24-IN-1 相关抗体:
分子量

499.54

Formula

C24H25N3O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRPF1B/TRIM24-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRPF1B/TRIM24-IN-11242907-48-7Epigenetic Reader DomainTripartite motif 24 proteinTRIM24BRPF1BRPF2MM1SRCH-ACHJJN3RKOMCF-7Inhibitorinhibitorinhibit

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