2. Protein Tyrosine Kinase/RTK Apoptosis
  3. c-Met/HGFR Apoptosis
  4. c-Met-IN-10

c-Met-IN-10 (compound 26a) 是一种高效的 c-Met 激酶抑制剂，IC50 为 16 nM。c-Met-IN-10 对癌细胞 A549、H460 和 HT-29 有抑制活性。c-Met-IN-10 抑制 HT-29 细胞集落形成，诱导 HT-29 和 A549 细胞凋亡 apoptosis，抑制 A549 细胞移动。c-Met-IN-10 可用于抗癌研究。

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c-Met-IN-10 Chemical Structure

c-Met-IN-10 Chemical Structure

CAS No. : 2415291-03-9

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c-Met-IN-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.59 μM
Compound: 26a
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32224380]
HT-29 IC50
0.56 μM
Compound: 26a
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32224380]
NCI-H460 IC50
0.72 μM
Compound: 26a
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32224380]
分子量

516.48

Formula

C26H21FN6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Met-IN-10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-102415291-03-9c-Met/HGFRApoptosisAnticancerColony formationCell motilityA549H460HT-29Inhibitorinhibitorinhibit

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