2. Others
  3. Others
  4. C6 Urea Ceramide

C6 Urea Ceramide  (Synonyms: C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-erythro-Urea-C6-Ceramide)

目录号: HY-139062
产品使用指南

摩尔计算器

C6 Urea Ceramide (C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea)是中性神经酰胺酶的抑制剂。它可增加野生型小鼠胚胎成纤维细胞 (MEF) 和 HT-29 结肠癌细胞中的总神经酰胺水平，但不会增加缺乏中性神经酰胺酶的 MEF 中的总神经酰胺水平。当浓度为 5 和 10 μM 时，它会抑制 HT-29 细胞的增殖，并诱导细胞凋亡和自噬，但不会诱导非癌性 RIE-1 细胞的凋亡和自噬。C6 Urea Ceramide 可降低 HT-29 和 HCT116 细胞中的总 β-catenin，增加磷酸化 β-catenin，并诱导 β-catenin 与 20S 蛋白酶体的共定位，但不会诱导 RIE-1 细胞中的共定位。当以 1.25、2.5 和 5 mg/kg 的剂量给药五天时，它可以减少肿瘤生长并增加 HT-29 小鼠异种移植模型中肿瘤组织中的 C16、C18、C20 和 C24 神经酰胺水平。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

C6 Urea Ceramide Chemical Structure

C6 Urea Ceramide Chemical Structure

CAS No. : 486991-52-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

C6 Urea Ceramide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C6 Urea Ceramide (C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells, but not in MEFs lacking neutral ceramidase. At concentrations of 5 and 10 μM, it inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but not in noncancerous RIE-1 cells. C6 Urea Ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116 cells, but not in RIE-1 cells. When administered at doses of 1.25, 2.5, and 5 mg/kg for five days, it reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.

分子量

426.68

Formula

C25H50N2O3
CAS 号
中文名称

D-赤型-N-[2-(1,3-二羟基-4E-十八碳烯)]-N'-己烷-脲-鞘氨醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

C6 Urea Ceramide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C6 Urea Ceramide486991-52-0C6 Ceramide (d18:1/6:0) Urea Cer(d18:1/6:0) Urea D-erythro-Urea-C6-CeramideD-赤型-N-[2-(1,3-二羟基-4E-十八碳烯)]-N'-己烷-脲-鞘氨醇OthersInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
C6 Urea Ceramide
目录号：
HY-139062
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z