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钙蛋白酶抑制剂具有亲脂性，与黑色素瘤细胞系（A-375和B-16F1）和PC-3前列腺癌细胞相比，他们在体外显示出中等到良好的抗增殖活性。此外，该组的一个成员（化合物3）在基质胶细胞侵袭测定中以2μM浓度抑制了80%的DU-145细胞侵袭。

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Calpain Inhibitor-2 Chemical Structure

Calpain Inhibitor-2 Chemical Structure

CAS No. : 2413962-65-7

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Calpain Inhibitor-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Calpain inhibitors are lipophilic and show moderate to good antiproliferative activity in vitro compared with melanoma cell lines (a-375 and b-16f1) and PC-3 prostate cancer cells. In addition, a member of this group (compound 3) expressed 2 μ M concentration inhibited the invasion of DU-145 cells by 80%.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 GI50
16 μM
Compound: 5
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
[PMID: 32199690]
B16-F1 GI50
17.2 μM
Compound: 5
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
[PMID: 32199690]
PC-3 GI50
6.02 μM
Compound: 5
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 32199690]
分子量

499.62

Formula

C26H33N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Calpain Inhibitor-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calpain Inhibitor-22413962-65-7Calpain Inhibitor2Calpain Inhibitor 2OthersInhibitorinhibitorinhibit

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