2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. CAP-53194

CAP-53194是一种选择性Plk1抑制剂，具有潜在的抗癌活性。CAP-53194通过分子对接的高通量虚拟筛选方法被识别，显示出对Plk1的100倍选择性，优于Plk2-4及其他细胞周期激酶。CAP-53194能够有效利用Plk1与其他Ser/Thr激酶的结合位点之间的细微差别，从而增强其抑制效果。CAP-53194满足Lipinski化合物类似物标准，并通过了其它ADMET过滤器，表明其良好的化合物可性。CAP-53194属于一种新的潜在Plk1抑制剂类，适用于后续的化合物开发和测试。

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CAP-53194 Chemical Structure

CAP-53194 Chemical Structure

CAS No. : 660817-08-3

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CAP-53194 相关抗体

Top Publications Citing Use of Products

查看 Polo-like Kinase (PLK) 亚型特异性产品:

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PLK1 PLK2 PLK3 PLK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing[1].

分子量

430.37

Formula

C21H14N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAP-53194 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAP-53194660817-08-3CAP53194CAP 53194Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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产品名称：
CAP-53194
目录号：
HY-123702
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