33069-62-4

生物活性： 姜黄素（二苯甲酰甲烷）是一种天然酚类化合物，是 p300/CREB 结合蛋白特异性乙酰转移酶抑制剂，可抑制组蛋白/非组蛋白的乙酰化和组蛋白乙酰转移酶依赖性染色质转录。姜黄素对 NF-κB 和 MAPK 有抑制作用，具有抗炎、抗氧化、抗增殖和抗血管生成等多种药理作用。姜黄素通过 Keap1 半胱氨酸修饰诱导 Nrf2 蛋白稳定。

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.