143984-17-2

生物活性：Y-29794 tosylate 是口服有效的非肽脯氨酰内肽酶 (PREP) 选择性抑制剂，IC₅₀ 为 3 nM， K_i 为 0.95 nM。Y-29794 tosylate 增强促甲状腺激素释放激素 (TRH) 对大鼠海马体内 ACh 释放的作用，具有神经保护潜力。Y-29794 tosylate 通过抑制 IRS1-AKT-mTORC1 通路表现出抗癌活性。Y-29794 tosylate 具有血脑屏障 (BBB) 通透性^[1][2]。

Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB)^[1][2].