1801151-15-4

生物活性：BMT-108908是一种负变构调节剂，具有对NMDA受体NR2B亚型的选择性活性。BMT-108908在研究中显示出对 cognition 的损害，影响多个领域的认知功能。BMT-108908在实验中未能表现出对脑电图γ波功率的显著影响，但对β波和δ波功率产生了明显的抑制和增强作用。BMT-108908的效果与其他NMDA受体通道阻滞剂如酮胺和兰尼莫的作用有所不同。

BMT-108908 is a negative allosteric modulator with selective activity on the NR2B subtype of the NMDA receptor. BMT-108908 has been shown to damage cognition in research, affecting cognitive functions in multiple areas. BMT-108908 failed to show a significant impact on the γ wave power of the EEG in the experiment, but it had a significant inhibitory and enhancement effect on the β wave and δ wave power. The effects of BMT-108908 differ from those of other NMDA receptor channel blockers such as ketamine and lanimol^[1].