1. Anti-infection Apoptosis MAPK/ERK Pathway NF-κB
  2. Bacterial Antibiotic Apoptosis p38 MAPK NF-κB
  3. 80214-83-1

80214-83-1

Roxithromycin Chemical Structure

Chemical Structure

80214-83-1

  • Roxithromycin
  • Synonym(s): RU-28965 ; 罗红霉素
  • CAS No.:80214-83-1
  • Formula:C41H76N2O15
  • Molecular Weight:837.05

生物活性:Roxithromycin (RU-28965) 是一种半合成的大环内酯类抗生素。Roxithromycin 通过与 50S 细菌核糖体结合,在延伸步骤中抑制蛋白质的生物合成。Roxithromycin 具有抑菌、抗增殖、抗炎、抑制肿瘤血管和改善肺损伤作用[1][2][3][4][5][6][7][8][9][10][11]

Roxithromycin (RU-28965) is an orally active semi-synthethic macrolide antibiotic. Roxithromycin inhibits protein biosynthesis in the elongation step by binding to 50S bacterial ribosome. Roxithromycin has antimicrobial, antiproliferative, anti-inflammatory, tumour vasculature inhibiting and lung injury ameliorating effects[1][2][3][4][5][6][7][8][9][10][11].

Cat. No. 产品名称 纯度 描述 价格
HY-B0435R Roxithromycin (Standard) ≥98% Roxithromycin (Standard)是 Roxithromycin 的分析标准品。本产品用于研究及分析应用。Roxithromycin (RU-28965) 是半合成的大环内酯类抗生素。

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规格 价格 是否有货 数量 操作
25 mg

¥300.00

In-stock
50 mg

¥460.00

In-stock
100 mg

¥700.00

In-stock
250 mg

¥1400.00

In-stock
HY-B0435 Roxithromycin 99.93% Roxithromycin (RU-28965) 是一种半合成的大环内酯类抗生素。Roxithromycin 通过与 50S 细菌核糖体结合,在延伸步骤中抑制蛋白质的生物合成。Roxithromycin 具有抑菌、抗增殖、抗炎、抑制肿瘤血管和改善肺损伤作用。

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规格 价格 是否有货 数量 操作
10 mM * 1mL

¥500.00

In-stock
500 mg

¥350.00

In-stock
1 g

¥450.00

In-stock
5 g

¥950.00

In-stock
10 g

¥1425.00

In-stock
HY-B0435S Roxithromycin-d7 98.28% Roxithromycin-d7 (RU-28965-d7) 是氘代标记的 Roxithromycin (HY-B0435)。Roxithromycin (RU-28965) 是一种半合成大环内酯类抗生素。

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规格 价格 是否有货 数量 操作
1 mg

¥6150.00

In-stock

References

[1]. Duewelhenke N, et al. Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. Antimicrob Agents Chemother. 2007 Jan;51(1):54-63. [Content Brief]
[2]. Takakusagi K, et al. Multimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin. Eur J Med Chem. 2015 Jan 27;90:809-21. [Content Brief]
[3]. Yamazaki H, et al. Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Drug Metab Dispos. 1998 Nov;26(11):1053-7. [Content Brief]
[4]. Bertho G, et al. Transferred nuclear Overhauser effect study of macrolide-ribosome interactions: correlation between antibiotic activities and bound conformations. Bioorg Med Chem. 1998 Feb;6(2):209-21. [Content Brief]
[5]. Chantot JF, et al. Antibacterial activity of roxithromycin: a laboratory evaluation. J Antibiot (Tokyo). 1986 May;39(5):660-8. [Content Brief]
[6]. Yatsunami J, et al. Inhibition of tumor angiogenesis by roxithromycin, a 14-membered ring macrolide antibiotic. Cancer Lett. 1998 Sep 25;131(2):137-43. [Content Brief]
[7]. Ito T, et al. Roxithromycin inhibits chemokine-induced chemotaxis of Th1 and Th2 cells but regulatory T cells. J Dermatol Sci. 2009 Jun;54(3):185-91. [Content Brief]
[8]. Takahashi H, et al. Roxithromycin decreases ultraviolet B irradiation-induced reactive oxygen intermediates production and apoptosis of keratinocytes. J Dermatol Sci. 2004 Feb;34(1):25-33. [Content Brief]
[9]. Zhang X, et al. Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells. Acta Pharmacol Sin. 2021 Dec;42(12):2058-2068. [Content Brief]
[10]. Ueno S, et al. Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clin Cancer Res. 2005 Aug 1;11(15):5645-50. [Content Brief]
[11]. Ci X, et al. Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma. Inflamm Res. 2012 Jul;61(7):749-58. [Content Brief]

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