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  3. Casein Kinase
  4. Casein Kinase II Inhibitor IV hydrochloride

Casein Kinase II Inhibitor IV hydrochloride 

目录号: HY-111378A
产品使用指南

摩尔计算器

Casein Kinase II Inhibitor IV Hydrochloride 是表皮角质形成细胞分化的小分子诱导剂。

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Casein Kinase II Inhibitor IV hydrochloride Chemical Structure

Casein Kinase II Inhibitor IV hydrochloride Chemical Structure

CAS No. : 2320347-54-2

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Casein Kinase II Inhibitor IV hydrochloride 的其他形式现货产品:

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Casein Kinase II Inhibitor IV hydrochloride 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation.

IC50 & Target

Target: Casein Kinase[1]
体外研究
(In Vitro)

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expresses loricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Casein Kinase II Inhibitor IV hydrochloride 相关抗体:
分子量

465.93

Formula

C24H24ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Kinase Assay
[1]

For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150 mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the human epidermal keratinocytes (NHEKs). After 24 h, the transfected cells are plated into 96-well assay plates and treated with Casein Kinase II Inhibitor IV to a final concentration of 5 μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Casein Kinase II Inhibitor IV hydrochloride 相关分类

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Casein Kinase II Inhibitor IV2320347-54-2Casein KinaseInhibitorinhibitorinhibit

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