2. PROTAC Apoptosis
  3. Molecular Glues Bcl-2 Family
  4. CCT373567

CCT373567 是一种有效的转录抑制因子 BCL6 分子胶 (molecular glue) 降解剂，IC50 值为 2.9 nM。CCT373567 具有抗增殖活性。

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CCT373567 Chemical Structure

CCT373567 Chemical Structure

CAS No. : 2378853-67-7

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CCT373567 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCT373567 is a potent molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.9 nM. CCT373567 exhibits antiproliferative activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT GI50
362 nM
Compound: 12b; CCT373567
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
KARPAS-422 GI50
38 nM
Compound: 12b; CCT373567
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
OCI-Ly1 GI50
83 nM
Compound: 12b; CCT373567
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
OCI-Ly3 GI50
2145 nM
Compound: 12b; CCT373567
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
SUD4 GI50
820 nM
Compound: 12b; CCT373567
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
分子量

547.00

Formula

C26H29ClF2N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCT373567 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT3735672378853-67-7CCT 373567CCT-373567Molecular GluesBcl-2 Familytranscriptional repressorBCL6antiproliferative activityInhibitorinhibitorinhibit

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产品名称：
CCT373567
目录号：
HY-146184
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