2. Membrane Transporter/Ion Channel
  3. BCRP
  4. CCTA-1523

CCTA-1523 是一种有效的、选择性的、可逆的和具有口服活性的 ABCG2 抑制剂。CCTA-1523 显示细胞毒性。CCTA-1523 显示出抗癌活性。

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CCTA-1523 Chemical Structure

CCTA-1523 Chemical Structure

CAS No. : 1616271-41-0

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规格 价格 是否有货 数量
1 mg ￥2210
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

CCTA-1523 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity[1].

体外研究
(In Vitro)

CCTA-1523 (0-1000 µM；72 小时) 对 H460、H460/MX20、HEK293/pcDNA3.1、HEK/R482、HEK/R482G 和 HEK/R482T 细胞具有细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CCTA-1523 相关抗体:
体内研究
(In Vivo)

CCTA-1523 (75 mg/kg；口服；q3d x 6) 与阿霉素 (HY-15142A) (1.8 mg/kg，腹腔注射，q3d X 6) 联合使用可抑制肿瘤生长并延长小鼠的生存时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCR nude mice (H460/MX20 xenografts)[1]
Dosage: 75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration: P.o.;q3d x 6
Result: Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
分子量

340.20

Formula

C16H15Cl2NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCTA-1523 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCTA-15231616271-41-0CCTA1523CCTA 1523BCRPBreast cancer resistance proteinABCG2anticancercytotoxicitydoxorubicinH460/MX20 xenograftsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-129301
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