2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. CDKL2-IN-1

CDK-IN-14 (Compound 9) 是一种有效的选择性 CDKL2 (Cyclin-dependent kinase-like 2，类细胞周期蛋白依赖性激酶 2) 抑制剂，IC50 值为 460 nM。CDKL2 与肿瘤形成、发育、病毒感染等生物学过程相关。CDK-IN-14 可作为研究 CDKL2 生物学作用的强大工具，有望用于癌症、感染等疾病领域的研究。

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CDKL2-IN-1 Chemical Structure

CDKL2-IN-1 Chemical Structure

CAS No. : 2471972-15-1

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CDKL2-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. CDK-IN-14 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1].

IC50 & Target

IC50: 460 nM (Cyclin-dependent kinase-like 2 (CDKL2))[1]
体外研究
(In Vitro)

CDK-IN-14 (0-4 μM, 1 小时) 通过抑制 CDKL2，干扰了大鼠初级神经元中 CDKL2 介导的下游信号传导，对 CDKL2 活性具有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDKL2-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: Rat primary neurons
Concentration: 0-4 μM
Incubation Time: 1 h
Result: Completely suppressed the CDKL2-mediated EB2 (microtubule end binding protein 2) phosphorylation in a dose-dependent manner.
分子量

426.53

Formula

C22H26N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDKL2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDKL2-IN-12471972-15-1Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesRat primary neuronsCancerInjectionInhibitorinhibitorinhibit

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