2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Endogenous Metabolite
  4. Cecropin P1, porcine acetate

Cecropin P1, porcine acetate 是一种抗菌 (antibacterial) 肽，可从猪小肠上部分离。Cecropin P1, porcine acetate 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine acetate 具有抗病毒 (antiviral) 活性，可抑制 PRRSV 感染。

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Custom Peptide Synthesis

Cecropin P1, porcine acetate Chemical Structure

Cecropin P1, porcine acetate Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Cecropin P1, porcine acetate 的其他形式现货产品:

Customer Review

Other Forms of Cecropin P1, porcine acetate:

Cecropin P1, porcine acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection[1][2].

体外研究
(In Vitro)

Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells[2].
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation[2].
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection[2].
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cecropin P1, porcine acetate 相关抗体:

Cell Viability Assay[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36, 48, 72, 96 h
Result: Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Inhibited CH-1a infection in Marc-145 cells with a 50% effective concentration (EC50) of 112 μg/mL. The 50% cytotoxic concentration (CC50) of Cecropin P1 for Marc-145 cells was estimated to be 719 μg/mL.

Western Blot Analysis[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36 h
Result: Significantly reduced the expression of the viral N protein when administered with either the pre-, co-, or posttreatment method.
体内研究
(In Vivo)

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3398.91

Formula

C₁₄₉H₂₅₇N₄₅O₄₅
Sequence Shortening

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Cecropin P1, porcine acetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cecropin P1, porcineBacterialEndogenous MetaboliteAntibacterial peptideMarc-145 cellsmacrophagesPRRSV infectionPorcine reproductive and respiratory syndromeantiviral activityCH-1a infectionseptic shockInhibitorinhibitorinhibit

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