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  4. Ceefourin 2

Ceefourin 2 是一种有效且高度选择性的 MRP4 抑制剂。Ceefourin 2 抑制 MRP4 底物的转运，但对其他 ABC 转运蛋白没有选择性。Ceefourin 2 具有较低的细胞毒性、较高的微粒体稳定性和酸稳定性。

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Ceefourin 2 Chemical Structure

Ceefourin 2 Chemical Structure

CAS No. : 348148-51-6

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Ceefourin 2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

体外研究
(In Vitro)

Ceefourin 2 对 MRP4 的选择性高于其他 ABC 转运蛋白，包括 P-糖蛋白 (P-gp)、ABCG2 (乳腺癌耐药蛋白；BCRP) 和 MRP1 (ABCC1)。Ceefourin 2 脱靶效应小，稳定性高[1]。
Ceefourin 2 (50 μM) 对两个正常 (HSF、MRC5) 、五个神经母细胞瘤 (BE(2)-C、IMR-32、IMR-32、SK-N-SH、SHEP) 和四个其他人类癌细胞系 (HEPG2、LNCap、SJ-G2、MCF7) 具有低细胞毒性 (IC50 >50 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ceefourin 2 相关抗体:
分子量

355.70

Formula

C15H9ClF3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ceefourin 2 相关分类

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  • 稀释计算器

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Keywords:

Ceefourin 2348148-51-6Ceefourin2Ceefourin-2OthersHEPG2LNCapSJ-G2MCF7Inhibitorinhibitorinhibit

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